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Guide for Authors
Guide for authors - Journal of Arthroplasty - ISSN
The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications to be administered or self-administered to patients , with the aim to cure them, vaccinate them, or alleviate the symptoms. They are subject to a variety of laws and regulations that govern the patenting , testing, safety, efficacy and marketing of drugs. The modern pharmaceutical industry began with local apothecaries that expanded from their traditional role distributing botanical drugs such as morphine and quinine to wholesale manufacture in the mids, and from discoveries resulting from applied research. By the s, the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. The blood pressure raising and vasoconstrictive effects of adrenal extracts were of particular interest to surgeons as hemostatic agents and as treatment for shock, and a number of companies developed products based on adrenal extracts containing varying purities of the active substance. In , John Abel of Johns Hopkins University identified the active principle as epinephrine , which he isolated in an impure state as the sulfate salt.
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