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Literature review iron overload

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Jana , Jianli Dong. Hereditary hemochromatosis HH is an autosomal recessive disorder of iron metabolism characterized by increased iron absorption and tissue deposition. It is well established that the phenotypic expression of HFE mutations varies markedly. Herein, we describe a year-old Caucasian woman with a reported history of hemochromatosis.
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An Overview of Iron Overload

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Iron Overload: Symptoms, Causes, Diagnosis, Treatment, and Coping

Iron overload can occur in people of any age, any ethnicity, or gender; iron overload is a condition of excess too much iron in the body. Excess iron in vital organs, even in mild cases of iron overload, increases the risk for liver disease cirrhosis, cancer , heart failure, diabetes mellitus, osteoarthritis, osteoporosis, metabolic syndrome, hypothyroidism, hypogonadism, numerous symptoms and in some cases premature death. Iron overload can be inherited genetic or acquired by receiving numerous blood transfusions, getting iron shots or injections, or consuming high levels of supplemental iron. Some of the genetic disorders that result in iron overload include are hereditary hemochromatosis all types , African iron overload, sickle cell disease, thalassemia, X-linked sideroblastic anemia, enzyme deficiencies pyruvate kinase; glucosephosphate dehydrogenase and very rare protein transport disorders aceruloplasminemia and atransferrinemia. None of these conditions should be confused with polycythemia vera PV , which is not an iron disorder, but a condition where the bone marrow produces too many blood cells red, white and platelet. People with PV have abnormally high hemoglobin and are at risk for a stroke and progressing to acute myelogenous leukemia AML. Part of the therapy for PV is phlebotomy.
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Iron overload

Also, to obtain patients' experiences of having iron overload and receiving infusion ICT, and experts' clinical opinions about the impact of treatment on patients' lives. Qualitative results from patient and expert interviews were analysed. Hand searching of relevant conference abstracts completed the search. QoL domains affected included: depression; fatigue; dyspnoea; physical functioning; psychological distress; decrease in QoL during hospitalization.
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Multiple myeloma is a hematologic malignancy that classically manifests with hypercalcaemia, renal insufficiency, anaemia and lytic bone lesions. Although transfusion-related hepatic iron overload—leading to significant liver disease—is a recognised complication in certain hematologic malignancies, little is known about transfusional iron overload in patients with multiple myeloma. A review of the literature on hepatic complications in multiple myeloma patients is presented. Keywords: multiple myeloma, iron overload, liver dysfunction, liver failure.
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Jake K. 01.05.2021
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